kaynakça 

 

1. Kumar, S., Purohit, C.S., Kulloli, R.N. (2020). Aloe trinervis sp. nov.: A new succulent species

from Indian Desert (Asphodelaceae). Journal of Asia-Pacific Biodiversity, 13, 325-330.

[Crossref]

2. Chase, M.W., De Bruijn, A.Y., Cox, A.V., Reeves, G., Rudall, P.J., Johnson, M.A.T., Eguiarte,

L.E. (2000). Phylogenetics of Asphodelaceae (Asparagales): An analysis of plastid rbcL and trnL[1]F DNA sequences. Annals of Botany, 86(5), 935–951. [Crossref]

3. Foster, M., Hunter, D., Samman, S. (2011). Evaluation of the Nutritional and Metabolic Effects

of Aloe vera. In: Benzie I.F.F. and Wachtel-Galor S. (Eds), Herbal Medicine: Biomolecular and

Clinical Aspects (pp. 37–54). Boca Raton: CRC Press.

4. Mahor, G., Ali, S.A. (2016). Recent update on the medicinal properties and use of Aloe vera in

the treatment of various ailments. Bioscience Biotechnology Research Communications, 9(2),

273–288.

5. Davis, P. (1984). Flora of Turkey and the East Aegean Islands, Vol. 8, (pp. 355-356). Edinburgh:

Edinburgh University Press.

6. Upton, R., Axentiev, P., Swisher, D. (2012). Aloe vera Leaf, Aloe vera Leaf Juice, Aloe vera Inner

Leaf Juice. In: Upton R. (Ed), American Herbal Pharmacopoeia, (pp. 1–52). California.

7. Gruenwald, J., Brendler, T., Jaenicke, C. (2000). Aloe vera. In: Fleming T. (Ed). Physician’s Desk

Reference (PDR) for Herbal Medicines: Herbal Monographs, (pp. 16–20). Montvale, New Jersey;

Medical Economics Company.

8. Zeybek, U., Haksel, M. (2011). Türkiye’de ve Dünyada Önemli Tıbbi Bitkiler ve Kullanımları,

ARGEFAR&Helvacızade Sağlık Yayınları, (pp.167-172). İzmir.

9. Baruah A, Bordoloi M, Deka Baruah HP. (2016). Aloe vera: A multipurpose industrial crop.

Industrial Crops and Products, 94, 951–963. [Crossref]

10. IARC Monographs (Online) (2015). International Agency for Research on Cancer (IARC), Vol.

108, (pp. 37–71). Lyon. [www.monographs.iarc]

11. World Health Organization (WHO) (1999). WHO Monographs on Selected Medicinal Plants

(Vol. 1). In: WHO Monographs on Selected Medical Plants. World Health Organization: Geneva,

Switzerland, (pp. 33–49).

12. Femenia, A., Sanchez, E.S., Simal, S., Rossello, C. (1999). Compositional features of

polysaccharides from Aloe vera (Aloe barbadensis Miller) plant tissues. Carbohydrate Polymers,

39, 109–117. [Crossref]

13. Boudreau, M.D., Beland, F.A. (2006). An evaluation of the biological and toxicological properties

of Aloe Barbadensis (Miller), Aloe Vera. Journal of Environmental Science and Health Part C,

24,103–154. [Crossref]

14. Bhuvana, K.B., Hema, N.G., Patil, R.T. (2014). Review on Aloe vera. International Journal of

Advanced Research, 2(3), 677–691.

15. Boudreau, M.D., Mellick, P.W., Olson, G.R., Felton, R.P., Thorn, B.T., Beland, F.A. (2013).

Clear evidence of carcinogenic activity by a whole-leaf extract of Aloe barbadensis Miller (Aloe

vera) in F344/N rats. Toxicological Sciences, 131(1), 26–39. [Crossref]

16. Cosmetic Ingredient Review Expert Panel (2007). Final Report on the Safety Assessment of Aloe

andongensis Extract, Aloe andongensis Leaf Juice, Aloe arborescens Leaf Extract, Aloe

arborescens Leaf Juice, Aloe arborescens Leaf Protoplasts, Aloe barbadensis Flower Extract,

Aloe barbadensis Leaf, Aloe bar. International Journal of Toxicology, 26(2),1-50. [Crossref]

17. Waller, G.R., Mangiafico, S., Ritchey, C.R. (1978). A chemical ınvestigation of Aloe barbadensis

Miller. Proceedings of the Oklahoma Academy of Science, 58, 69–76.

18. Raksha, B., Pooja, S., Babu, S. (2014). Bioactive compounds and medicinal properties of Aloe

vera L.: An update. Journal of Plant Sciences, 2(3), 102–107. [Crossref]

19. López, A., De Tangil, M.S., Vega-Orellana, O., Ramírez, A.S., Rico, M. (2013). Phenolic

constituents, antioxidant and preliminary antimycoplasmic activities of leaf skin and flowers of

Aloe vera (L.) Burm. f. (syn. A. barbadensis Mill.) from the Canary Islands (Spain). Molecules,

18, 4942–4954. [Crossref]

20. Wink, M. (2003). Evolution of secondary metabolites from an ecological and molecular

phylogenetic perspective. Phytochemistry, 64, 3–19. [Crossref]

21. Hamman, J.H. (2008). Composition and applications of Aloe vera leaf gel. Molecules, 13(8),

1599–1616. [Crossref]

22. Ahlawat, K.S., Khatkar, B.S. (2011). Processing, food applications and safety of Aloe vera

products: A review. Journal of food science and technology, 48(5), 525–533. [Crossref]

23. Rodríguez, E.R., Martín, J.D., Romero, C.D. (2010). Aloe vera as a Functional Ingredient in

Foods. Critical Reviews in Food Science and Nutrition, 50, 305–326. [Crossref]

24. Brusick, D., Mengs, U. (1997). Assessment of the genotoxic risk from laxative senna products.

Environmental and Molecular Mutagenesis, 29(1), 1–9. [Crossref]

25. Mascolo, N., Izzo, A.A., Borrelli, F., Capasso, R., Di Carlo, G., Sautebin, L., Capasso, F. (2004).

Healing Powers of Aloes. In: Reynolds T. (Ed), Aloes: The Genus Aloe (e-Book), (pp. 222–251 Boca Raton: CRC Press.

26. European Scientific Cooperative on Phytotherapy (ESCOP). (2014). Aloe barbadensis (Barbados

Aloes). In: Mills S, Hutchins R, (Eds), ESCOP Monographs. Exeter, UK: ESCOP.

27. Motykie, G.D., Obeng, M.K., Heggers, J.P. (2004). Aloe vera in wound healing. In: Reynolds T.

(Ed), Aloes: The Genus Aloe (e-Book), (pp. 252–263). Boca Raton: CRC Press.

28. Sung, C.K. (2006). The History of Aloe. In: Park Y.I., Lee S.K. (Eds). New Perspectives on Aloe

(e-Book), (pp. 7–9). New York: Springer.

29. Georgescu, M., Marinas, O., Popa, M., Stan, T., Lazar, V., Bertesteanu, S.V., Chifıriuc, M.

(2016). Natural Compounds for Wound Healing. In: Worldwide Wound Healing - Innovation in

Natural and Conventional Methods. (pp. 61–89).

30. Ross, I.A. (2001). Medicinal Plants of the World: Chemical constituents, traditional and modern

medicinal uses. Vol. 3 (e-Book). Humana Press.

31. Hormozi, M., Assaei, R., Boroujeni, M.B. (2017). The effect of Aloe vera on the expression of

wound healing factors (TGFβ1 and bFGF) in mouse embryonic fibroblast cell: In vitro study.

Biomedicine&Pharmacotherapy, 88, 610–616. [Crossref]

32. Subramanian, S., Sathish Kumar, D., Arulselvan P. (2006). Wound healing potential of Aloe vera

leaf gel studied in experimental rabbits. Asian Journal of Biochemistry, 1(2),178–185. [Crossref]

33. Sánchez-Machado, D.I., López-Cervantes, J., Sendón, R., Sanches-Silva, A. (2017). Aloe vera:

Ancient knowledge with new frontiers. Trends in Food Science&Technology, 61, 94–102.

[Crossref]

34. Fox, L.T., Mazumder, A., Dwivedi, A., Gerber, M., du Plessis, J., Hamman, J.H. (2017). In vitro

wound healing and cytotoxic activity of the gel and whole-leaf materials from selected Aloe

species. Journal of Ethnopharmacology, 200, 1–7. [Crossref]

35. Visuthikosol, V., Chowchuen, B., Sukwanarat, Y., Sriurairatana, S., Boonpucknavig, V. (1995).

Effect of Aloe vera gel to healing of burn wound a clinical and histologic study. Journal of the

Medical Association of Thailand, 78(8), 403-409.

36. Bahramsoltani, R., Farzaei, M.H., Rahimi, R. (2014). Medicinal plants and their natural

components as future drugs for the treatment of burn wounds: An integrative review. Archives of

Dermatological Research, 306(7), 601–617. [Crossref]

37. Hashemi, S.A., Madani, S.A., Abediankenari, S. (2015). The review on properties of Aloe vera

in healing of cutaneous wounds. BioMed Research International, 2015, 714216. [Crossref]

38. Kumar, S., Yadav, J.P. (2014). Ethnobotanical and pharmacological properties of Aloe vera: a

review. Journal of Medicinal Plants Research, 8(48), 1387–1398.

39. Pugh, N., Ross, S.A., ElSohly, M.A., Pasco, D.S. (2001). Characterization of aloeride, a new

high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity.

Journal of Agricultural and Food Chemistry, 49(2), 1030–1034. [Crossref]

40. Ozsoy, N., Candoken, E., Akev, N. (2009). Implications for degenerative disorders: antioxidative

activity, total phenols, flavonoids, ascorbic acid, β-carotene and α-tocopherol in Aloe vera.).

Oxidative Medicine and Cellular Longevity, 2(2), 99–106.

41. Kaithwas, G., Singh, P., Bhatia, D. (2014). Evaluation of in vitro and in vivo antioxidant potential

of polysaccharides from Aloe vera (Aloe barbadensis Miller) gel. Drug and Chemical Toxicology,

37(2), 135–143. [Crossref]

42. Rodrigues Oliveira, L.L., de Oliveira, A.C.L., Tabrez, S., Shakil, S., Khan, M.I., Asghar, M.N.,

Matias, B.D., Alves da Silva Batista, J.M., Rosal, M.M., Fulgencio de Lima, M.M.D., Ferreira

Gomes, S.R., de Carvalho, R.M., de Moraes, G.P., Oliveira Barros de Alencar, M.V., Islam, M.T.,

de Carvalho Melo-Cavalcante, A.A. (2018). Mutagenic, antioxidant and wound healing properties

of Aloe vera. Journal of Ethnopharmacology, 227, 191–197. [Crossref]

43. Capasso, F., Borrelli, F., Capasso, R., Di Carlo, G., Izzo, A.A., Pinto, L, Mascolo, N., Castaldo,

S., Longo, R. (1998). Aloe and its therapeutic use. Phytotherapy Research, 12, 124–127.

[Crossref]

44. Tizard, I.R., Ramamoorthy, L. (2004). Aloes and the immun system. In: Reynolds T. (Ed), Aloes:

The Genus Aloe (e-Book), (pp. 324–45). Boca Raton: CRC Press

45. Lee, W., Yang, S., Lee, C., Park, E.K., Kim, K.M., Ku, S.K., Bae, J.S. (2019). Aloin reduces

inflammatory gene iNOS via inhibition activity and p-STAT-1 and NF-κB. Food and Chemical

Toxicology, 126, 67–71. [Crossref]

46. Heng, H.C., Zulfakar, M.H., Ng P.Y. (2018), Pharmaceutical Applications of Aloe vera.

Indonesian Journal of Pharmacy, 29(3), 101–116. [Crossref]

47. Maan, A.A., Nazir, A., Khan, M.K.I., Ahmad, T., Zia, R., Murid, M, Abrar, M. (2018). The

therapeutic properties and applications of Aloe vera: A review. Journal of Herbal Medicine, 12,

1-10. [Crossref]

48. Salehi, B., Albayrak, S., Antolak, H., Kręgiel, D., Pawlikowska, E., Sharifi-Rad, M., Uprety, Y.,

T souh Fokou, P.V., Yousef, Z., Zakaria, Z.A., Varoni E.M., Sharopov, F., Martins, N., Iriti M.,

Sharifi-Rad, J. (2018). Aloe genus plants: From farm to food applications and

phytopharmacotherapy. International Journal of Molecular Sciences, 19(9), 2843. [Crossref]

49. Surjushe, A., Vasani, R., Saple, D. (2008). Aloe vera: A short review. Indian Journal of

Dermatology, 53(4), 163–166.

50. Steenkamp, V., Stewart, M.J. (2007). Medicinal applications and toxicological activities of Aloe

products. Pharmaceutical Biology. 45(5), 411–420. [Crossref]

51. Akev, N. (2007). Effect of Aloe vera pulp extract on Ehrlich ascites tumours in mice. European

Journal of Cancer Prevention, 16(2), 151-157. [Crossref]

52. El-Shemy, H., Aboul-Soud, M., Aboul-Enein, K., Nassr-Allah, A., Kabash, A., Yagi, A. (2010).

Antitumor properties and modulation of antioxidant enzymes activity by Aloe vera leaf active

principles isolated via supercritical carbon dioxide extraction. Current Medicinal Chemistry,

17(2), 129–138. [Crossref]

53. Tomasin, R., Gomes-Marcondes, M.C.C. (2011). Oral administration of Aloe vera and honey

reduces walker tumour growth by decreasing cell proliferation and increasing apoptosis in tumour

tissue. Phytotherapy Research, 25, 619–623. [Crossref]

54. Liu, R.H. (2004). Potential synergy of phytochemicals in cancer prevention: mechanism of action.

The Journal of Nutrition, 134(12), 3479–3485. [Crossref]

55. Akaberi, M., Sobhani, Z., Javadi, B., Sahebkar, A., Emami, S.A. (2016). Therapeutic effects of

Aloe spp. in traditional and modern medicine: A review. Biomedicine&Pharmacotherapy, 84,

759–772. [Crossref]

56. Halder, S., Mehta, A.K., Mediratta, P.K. (2013). Aloe vera improves memory and reduces

depression in mice. Nutritional Neuroscience, 16(6), 250–254. [Crossref]

57. Abdollahnejad, F., Mosaddegh, M., Nasoohi, S., Mirnajafi-Zadehc, J., Kamalinejadd, M., Faizi,

M. (2016). Study of sedative-hypnotic effects of Aloe vera L. aqueous extract through behavioral

evaluations and EEG recording in rats. Iranian Journal of Pharmaceutical Research, 15(1), 293–

300.

58. Shida, T., Yagi, A., Nishimura H., Nishioka, I. (1985). Effect of Aloe extract on peripheral

phagocytosis in adult bronchial asthma. Planta Medica, 51(3), 273–275. [Crossref]

59. Kar, A., Panda, S., Bharti, S. (2002). Relative efficacy of three medicinal plant extracts in the

alteration of thyroid hormone concentrations in male mice. Journal of Ethnopharmacology, 81(2),

281–285. [Crossref]

60. EMA Committee on Herbal Medicinal Products (HMPC). (2017). European Union herbal

monograph on Aloe barbadensis Mill . and on Aloe ( various species , mainly Aloe ferox Mill .

and its hybrids), folii succus siccatus. European Medicines Agency: London.

61. Gıda ve Kontrol Genel Müdürlüğü web sitesi. (2018). Aloe vera (L.) Burm. f.’nin Yapraklarından

Elde Edilen Aloe vera Jel ve Renksizleştirilmiş Yaprak Usaresi’nin Gıdalarda Kullanımının

Güvenilirliğinin Değerlendirilmesi Hakkında Bilimsel Görüş. From [www.tarimorman.gov.tr]

Erişim tarihi: 18.02.2019.

62. U.S. FDA. (2002). U.S. Food and Drug Administration - Status of Certain Additional Over-the[1]Counter Drug Category II and III Active Ingredients. Vol. 67. No. 90 / Thursday, May 9, 2002 /

Rules and Regulations. 21 CFR Part 310.

63. Shahzad, M.N., Ahmed, N. (2013). Effectiveness of Aloe vera gel compared with 1% silver

sulphadiazine cream as burn wound dressing in second degree burns. The Journal of the Pakistan

Medical Association, 63(2), 225–230.

64. Irani, P.S., Varaie, S. (2016). Comparison of the effect of Aloe vera gel and nitrofurazone 2% on

epithelialization and granulation tissue formation regarding superficial second-degree burns.

Iranian Journal of Medical Sciences, 41(3), S3.

65. Najafian, Y., Khorasani, Z.M., Najafi, M.N., Hamedi, S., Mahjour, M., Feyzabadi, Z. (2019).

Efficacy of Aloe vera/Plantago major gel in diabetic foot ulcer: A randomized double-blind

clinical trial. Current Drug Discovery Technologies, 16(2), 223-231. [Crossref]

66. Avijgan, M., Alinaghian, M., Esfahani, M.H. (2017). Aloe vera gel as a traditional and

complementary method for chronic skin burn: A case report. Advances in Infectious Diseases.

7(1), 19–25. [Crossref]

67. Avijgan, M., Kamran, A., Abedini, A. (2016). Effectiveness of Aloe vera Gel in Chronic Ulcers

in Comparison with Conventional Treatments (Poster). Iranian Journal of Medical Sciences. 41(3), S30.

68. Panahi, Y. (2015). Comparative trial of Aloe vera/olive oil combination cream versus phenytoin

cream in the treatment of chronic wounds. Journal of Wound Care, 24(10), 62–65. [Crossref]

69. Molazem, Z., Mohseni, F., Younesi, M., Keshavarzi, S. (2014). Aloe vera gel and cesarean wound

healing: A randomized controlled clinical trial. Global Journal of Health Science, 7(1), 203–209.

[Crossref]

 

 

70. Syed, T.A. (1996). Management of psoriasis with Aloe vera extract in a hydrophilic cream: A

placebo-controlled, double-blind study. Tropical Medicine and International Health, 1(4), 505–

509. [Crossref]

71. Seyger, M.M.B., Van De Kerkhof, P.C.M., Van Vlijmen-Willems, I.M.J.J., De Bakker, E.S.M.,

Zwiers, F., De Jong, E.M.G.J. (1998). The efficacy of a new topical treatment for psoriasis: Mirak.

The Journal of the European Academy of Dermatology and Venereology, 11, 13–18. [Crossref]

72. Haddad, P., Amouzgar-Hashemi, F., Samsami, S., Chinichian, S., Oghabian, M.A. (2013). Aloe

vera for prevention of radiation-induced dermatitis: A self-controlled clinical trial. Current

Oncology, 20, 345–348. [Crossref]

73. Yogi, V., Singh, O.P., Mandloi, V., Ahirwar, M. (2018). Role of topical Aloe vera gel in the

recovery of high-grade, radiation-induced dermatitis. Clinical Cancer Investigation Journal, 7,

167–170. [Crossref]

74. Paulsen, E., Korsholm, L., Brandrup, F. (2005). A double-blind, placebo-controlled study of a

commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. The Journal of

the European Academy of Dermatology and Venereology, 19, 326–331. [Crossref]

75. Choonhakarn, C., Busaracome, P., Sripanidkulchai, B., Sarakarn, P. (2010). A prospective,

randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild

to moderate plaque psoriasis. The Journal of the European Academy of Dermatology and

Venereology, 24, 168–172. [Crossref]

76. Ahmadloo, N., Kadkhodaei, B., Omidvari, S., Mosalaei, A., Ansari, M., Nasrolahi, H., Hamedi

S.H., Mohammadianpanah, M. (2017). Lack of Prophylactic Effects of Aloe vera Gel on

Radiation Induced Dermatitis in Breast Cancer Patients. Asian Pacific Journal of Cancer

Prevention, 18(4), 1139–1143.[Crossref]

77. Merchant, T.E., Bosley, C., Smith,J., Baratti, P., Pritchard, D., Davis, T., Li, C., Xiong, X. (2007).

A phase III trial comparing an anionic phospholipid-based cream and Aloe vera-based gel in the

prevention of radiation dermatitis in pediatric patients. Radiation Oncology, 2, 45. [Crossref]

78. Olsen, D.L., Raub, W., Bradley, C., Johnson, M., Macias, J.L., Love, V., Markoe, A. (2001). The

effect of Aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients

undergoing radiation therapy. Oncology Nursing Forum, 28(3), 543-547.

79. Hoopfer, D., Holloway, C., Gabos, Z., Alidrisi, M., Chafe, S., Krause, B., Lees, A., Mehta, N.,

Tankel, K., Strickland, F., Hanson, J., King, C., Ghosh, S., Severin, D. (2015). Three-arm

randomized phase III trial: Quality Aloe and placebo cream versus powder as skin treatment

during breast cancer radiation therapy. Clinical Breast Cancer, 15(3), 181-190.e4. [Crossref] in cancer radiation: An updated comprehensive review. Complementary Therapies in Clinical

Practice, 35, 126–130. [Crossref]

80. Farrugia, C.J.E., Burke, E.S., Haley, M.E., Bedi, K.T., Gandhi, M.A. (2019). The use of Aloe vera

81. Yee, C., Wang, K., Asthana, R., Drost, L., Lam, H., Lee, J., Vesprini, D., Leung, E., Deangelis,

C., Chow, E. (2018). Radiation-induced skin toxicity in breast cancer patients: A systematic

review of randomized trials. Clinical Breast Cancer, 18(5), 825–840. [Crossref]

82. Chew, Y.L., Al-Nema, M., Ong, V.W.M. (2018). Management and treatment of atopic dermatitis

with modern therapies, complementary and alternative medicines: a review. Oriental Pharmacy

and Experimental Medicine, 18, 67–76. [Crossref]

83. Hajheydari, Z., Saeedi, M., Morteza-Semnani, K., Soltani, A. (2014). Effect of Aloe vera topical

gel combined with tretinoin in treatment of mild and moderate acne vulgaris: A randomized,

double-blind, prospective trial. Journal of Dermatological Treatment, 25(2), 123–129. [Crossref]

84. Mazzarello, V., Donadu, M., Ferrari, M., Piga, G., Usai, D., Zanetti, S., Sotgiu, M.A. (2018).

Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to

erythromycin cream: two double-blind investigations. Clinical Pharmacology: Advances and

Applications, 10, 175–181. [Crossref]

85. Syed, T.A. (1996). Aloe vera extract 0.5% in hydrophilic cream versus Aloe vera gel for the

management of genital herpes in males. A placebo-controlled, douhle- blind, comparative study.

The Journal of the European Academy of Dermatology and Venereology, 7, 294–5. [Crossref]

86. Syed, T.A., Afza, M., Ahmad, S.A., Holt, A., Ahmad, S.A., Ahmad, S. (1997). Management of

genital herpes in men with 0.5% Aloe vera extract in a hydrophilic cream: A placebo-controlled

double-blind study. Journal of Dermatological Treatment, 8, 99–102. [Crossref]

87. Vardy, D., Cohen, A., Tchetov, T., Medvedovsky, E., Biton, A. (1999). A double-blind, placebo[1]controlled trial of an Aloe vera (A . barbadensis) emulsion in the treatment of seborrheic

dermatitis. Journal of Dermatological Treatment, 10(1), 7–11. [Crossref]

88. Panahi, Y., Sharif, M.R., Sharif, A., Beiraghdar, F., Zahiri, Z., Amirchoopani, G., Marzony, E.T.,

Sahebkar, A. (2012). A randomized comparative trial on the therapeutic efficacy of topical Aloe

vera and Calendula officinalis on diaper dermatitis in children. The Scientific World Journal,

2012, 810234. [Crossref]

89. Badelbuu, S.G., Javadzadeh, Y., Jabraeili, M., Heidari, S., Bostanabad, M.A. (2018). Evaluation

of the effect of Aloe vera ointment with chamomile ointment on severity of children’s diaper

dermatitis: A randomized, double-blind clinical trial. Middle East Journal of Family Medicine,

16(3), 47–51.

90. Zhang, Y., Liu, W., Liu, D., Zhao, T., Tian, H. (2016). Efficacy of Aloe vera supplementation on

prediabetes and early non-treated diabetic patients: A systematic review and meta-analysis of

randomized controlled trials. Nutrients. 8(7), 388. [Crossref]

91. Walid, R., Hafida, M., Abdelhamid, E.H.I., Reda, B., Rachid, A., Mohamed, B. (2018). Beneficial

effects of Aloe vera gel on lipid profile, lipase activities and oxidant/antioxidant status in obese

rats. Journal of Functional Foods, 48, 525–532. [Crossref]

92. Choi, H.C., Kim, S.J., Son, K.Y., Oh, B.J., Cho, B.L. (2013). Metabolic effects of Aloe vera gel

complex in obese prediabetes and early non-treated diabetic patients: Randomized controlled trial.

Nutrition, 29(9), 1110–1114. [Crossref]

93. Yun, J.M., Singh, S., Jialal, R., Rockwood, J., Jialal, I., Devaraj, S. (2010). A randomized

placebo-controlled crossover trial of Aloe vera on bioavailability of Vitamins C and B12, blood

glucose, and lipid profile in healthy human subjects. Journal of Dietary Supplements. 7(2), 145–

153. [Crossref]

94. Mentreddy, S., Mohamed, A., Rimando, A. (2005). Medicinal plants with hypoglycemic/ anti[1]hyperglycemic properties: A review. Association for the Advancement of Industrial Crops

Conference, 20, 341–353.

95. Reynolds, T., Dweck, A.C. (1999). Aloe vera leaf gel: A review update. Journal of

Ethnopharmacology. 68(1–3), 3–37. [Crossref]

96. Park, C.H., Son, H.U., Yoo, C.Y., Lee, S.H. (2017). Low molecular-weight gel fraction of Aloe

vera exhibits gastroprotection by inducing matrix metalloproteinase-9 inhibitory activity in

alcohol-induced acute gastric lesion tissues. Pharmaceutical Biology, 55(1), 2110–2115.

[Crossref]

97. Gopinathan, S., Rameela, N. (2014). Anti-ulcer activity of aloe vera juice and Aloe vera and amla

fruit combined juice in ethanol induced ulcerated rats. International Journal of Pharmacy and

Pharmaceutical Sciences, 6(6), 190–197.

98. Keshavarzi, Z., Rezapour, T.M., Vatanchian, M., Hesari, M.Z., Haghighi, H.N., Izanlu, M.,

Sabaghian, M., Shahveisi, K. (2014). The effects of aqueous extract of Aloe vera leaves on the

gastric acid secretion and brain and intestinal water content following acetic acid- induced gastric

ulcer in male rats. Avicenna Journal of Phytomedicine, 4(2), 137–143.

99. Panahi, Y. (2015). Efficacy and safety of Aloe vera syrup for the treatment of gastroesophageal

reflux disease: A pilot randomized positive-controlled trial. Journal of Traditional Chinese

Medicine. 35(6), 632–636. [Crossref]

100. Hong, S.W., Chun, J., Park, S., Lee, H.J., Im, J.P., Kim, J.S. (2018). Aloe vera ıs effective and

safe in short-term treatment of ırritable bowel syndrome: A systematic review and meta-analysis.

Journal of Neurogastroenterology and Motility, 24(4), 528–535. [Crossref]

101. Langmead, L. (2004). Randomized, double-blind, placebo-controlled trial of oral Aloe vera gel

for active ulcerative colitis. Alimentary Pharmacology&Therapeutics, 19(7), 739–747. [Crossref]

102. Rahmani, N., Khademloo, M., Vosoughi, K., Assadpour, S. (2014). Effects of Aloe vera cream

on chronic anal fissure pain, wound healing and hemorrhaging upon defection: A prospective

double blind clinical trial. European Review for Medical and Pharmacological Sciences, 18,

1078–1084.

103. Alinejad-Mofrad, S., Foadoddini, M., Saadatjoo, S.A., Shayesteh, M. (2015). Improvement of

glucose and lipid profile status with Aloe vera in pre-diabetic subjects: A randomized controlled[1]trial. Journal of Diabetes & Metabolic Disorders, 14, 22. [Crossref]

104. Zarrintan, A., Mobasseri, M., Zarrintan, A., Ostadrahimi, A. (2015). Effects of Aloe vera

supplements on blood glucose level and lipid profile markers in type 2 diabetic patients: A

randomized clinical trial. Pharmaceutical Sciences, 21, 65–71. [Crossref]

105. Huseini, H.F., Kianbakht, S., Hajiaghaee, R., Dabaghian, F.H. (2012) Anti-hyperglycemic and

anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Planta Medica, 78, 311–316.

[Crossref]

106. Yagi, A., Hegazy, S., Kabbash, A., Wahab, E.A.E. (2009). Possible hypoglycemic effect of Aloe

vera L. high molecular weight fractions on type 2 diabetic patients. Saudi Pharmaceutical

Journal, 17(3), 209–215. [Crossref]

107. Al-Maweri, S.A., Ashraf, S., Lingam, A.S., Alqutaibi, A., Abdulrab, S., Alaizari, N., Halboub, E.

(2018). Aloe vera in treatment of oral submucous fibrosis: A systematic review and meta-analysis.

Journal of Oral Pathology and Medicine, 48(2), 99-107. [Crossref]

108. Nair, G.R. (2016). Clinical Effectiveness of Aloe vera in the Management of Oral Mucosal

Diseases-A Systematic Review. Journal of Clinical and Diagnostic Research. 10(8), ZE01–7.

[Crossref]

109. Gao,Y., Kuok, K.I., Jin, Y., Wang, R. (2018). Biomedical applications of Aloe vera. Critical

Reviews in Food Science and Nutrition, 59(1), S244-S256. [Crossref]

110. Koga, A.Y., Pereira, A.V., Lipinski, L.C., Oliveira, M.R.P. (2018). Evaluation of wound healing

effect of alginate films containing Aloe vera (Aloe barbadensis Miller) gel. Journal of

Biomaterials Applications, 32(9), 1212–1221. [Crossref]

111. Pereira, G.G., Guterres, S.S., Balducci, A.G., Colombo, P., Sonvico, F. (2014). Polymeric films

loaded with vitamin e and Aloe vera for topical application in the treatment of burn wounds.

BioMed Research International, 2014, 641590. [Crossref]

112. Krishnaveni, V., Aparna, B. (2014). Microencapsulation of copper enriched Aloe gel curative

garment for atopic dermatitis. Indian Journal of Traditional Knowledge, 13(4), 795–803.

113. Ghayempour, S., Montazer, M., Mahmoudi Rad, M. (2016). Encapsulation of Aloe vera extract

into natural Tragacanth Gum as a novel green wound healing product. International Journal of

Biological Macromolecules, 93, 344–349. [Crossref]

114. Tippayawat, P., Phromviyo, N., Boueroy, P., Chompoosor, A. (2016). Green synthesis of silver

nanoparticles in Aloe vera plant extract prepared by a hydrothermal method and their synergistic

antibacterial activity. PeerJ, 4, e2589. [Crossref]

115. Morgan, M., Bone, K., Mills, S., McMillan, J. (2005). Aloe: Safety monograph. In S. Mills ve K.

Bone (Eds.), The essential guide to herbal safety (pp. 233–240). St. Louis (MO): Elsevier

Churchill Livingstone.

116. Gupta, RC., Chang, D., Nammi, S., Bensoussan, A., Bilinski, K., Roufogalis, BD. (2017).

Interactions between antidiabetic drugs and herbs: An overview of mechanisms of action and

clinical implications. Diabetology and Metabolic Syndrome, 9, 59. [Crossref]

117. Braun, L., Cohen, M. (2007). Herbs ve Natural Supplements, Elsevier, Australia.

118. Parlati, L., Voican, C.S., Perlemuter, K., Perlemuter, G. (2017). Aloe vera-induced acute liver

injury: A case report and literature review. Clinics and Research in Hepatology and

Gastroenterology, 41(4), e39–e42. [Crossref]

119. Tekin, F., Şahin, O. Z., Karasu, Z., Nart, D., Özütemiz, Ö., Ersöz, G., Batur, Y., İlter, T. (2006).

Aloe vera’ya bağlı ciddi toksik hepatit:Olgu sunumu. Akademik Gastroenteroloji Dergisi, 5(2), 134–136.

120. Kanat, O., Ozet, A., Ataergin, S. (2006). Aloe vera-induced acute toxic hepatitis in a healthy

young man. European Journal of Internal Medicine, 17, 589.[Crossref]

121. Baretta, Z., Ghiotto, C., Marino, D., Jirillo, A. (2009). Aloe-induced hypokalemia in a patient with

breast cancer during chemotherapy. Annals of Oncology, 20, 1445–1446. [Crossref]

122. Maenthaisong, R., Chaiyakunapruk, N., Niruntraporn, S., Kongkaew, C. (2007). The efficacy of

Aloe vera used for burn wound healing: A systematic review. Burns, 33, 713–718. [Crossref]

123. National Toxicology Program. (2016). Aloe vera Fact Sheet. From [www.niehs.nih.gov] Erişim

tarihi: 08.04.2018.

124. International Aloe Science Council (IASC). (2013). Aloe vera Quality Standard. From

[www.iasc.org] Erişim tarihi: 03.04.2018.

125. International Aloe Science Council (IASC). (2009). IASC Labeling Guidance. From

[www.iasc.org] Erişim tarihi: 03.04.2018.

126. NCCIH. (2016). Aloe Vera. From [nccih.nih.gov] Erişim tarihi: 16.04.2019.

127. European Food Safety Authority (EFSA). (2012). Compendium of botanicals reported to contain

naturally occuring substances of possible concern for human health when used in food and food

supplements. EFSA Journal, 10(5):2663.

128. EMA Committee on Herbal Medicinal Products (HMPC). (2016). Assessment report on Aloe

barbadensis Mill. and on Aloe (various species, mainly Aloe ferox Mill. and its hybrids), folii

succus siccatus. From [www.ema.europa.eu] Erişim tarihi: 06.12.2018.

129. The European Community. (2008). European Community Position Codex Committee On Food

Additives. From [ec.europa.eu] Erişim tarihi: 11.11.2018.

130. Radha, M.H., Laxmipriya, N.P. (2015). Evaluation of biological properties and clinical

effectiveness of Aloe vera: A systematic review. Journal of Traditional and Complementary

Medicine, 5(1), 21–26. [Crossref]

131. Fox, L.T., Mazumder, A., Dwivedi, A., Gerber, M., du Plessis, J., Hamman, J.H. (2017). In vitro

wound healing and cytotoxic activity of the gel and whole-leaf materials from selected Aloe

species. Journal of Ethnopharmacology, 200, 1–7. [Crossref]

132. Habtemariam, S. (2017). Could We Really Use Aloe vera Food Supplements to Treat Diabetes?

Quality Control Issues. Evidence-Based Complementary and Alternative Medicine, 2017,

4856412. [Crossref]

133. Ankara Ecz. Fak. Derg., 45(3): 674-698, 2021