1. Kumar, S., Purohit, C.S., Kulloli, R.N. (2020). Aloe trinervis sp. nov.: A new succulent species
from Indian Desert (Asphodelaceae). Journal of Asia-Pacific Biodiversity, 13, 325-330.
[Crossref]
2. Chase, M.W., De Bruijn, A.Y., Cox, A.V., Reeves, G., Rudall, P.J., Johnson, M.A.T., Eguiarte,
L.E. (2000). Phylogenetics of Asphodelaceae (Asparagales): An analysis of plastid rbcL and trnL[1]F DNA sequences. Annals of Botany, 86(5), 935–951. [Crossref]
3. Foster, M., Hunter, D., Samman, S. (2011). Evaluation of the Nutritional and Metabolic Effects
of Aloe vera. In: Benzie I.F.F. and Wachtel-Galor S. (Eds), Herbal Medicine: Biomolecular and
Clinical Aspects (pp. 37–54). Boca Raton: CRC Press.
4. Mahor, G., Ali, S.A. (2016). Recent update on the medicinal properties and use of Aloe vera in
the treatment of various ailments. Bioscience Biotechnology Research Communications, 9(2),
273–288.
5. Davis, P. (1984). Flora of Turkey and the East Aegean Islands, Vol. 8, (pp. 355-356). Edinburgh:
Edinburgh University Press.
6. Upton, R., Axentiev, P., Swisher, D. (2012). Aloe vera Leaf, Aloe vera Leaf Juice, Aloe vera Inner
Leaf Juice. In: Upton R. (Ed), American Herbal Pharmacopoeia, (pp. 1–52). California.
7. Gruenwald, J., Brendler, T., Jaenicke, C. (2000). Aloe vera. In: Fleming T. (Ed). Physician’s Desk
Reference (PDR) for Herbal Medicines: Herbal Monographs, (pp. 16–20). Montvale, New Jersey;
Medical Economics Company.
8. Zeybek, U., Haksel, M. (2011). Türkiye’de ve Dünyada Önemli Tıbbi Bitkiler ve Kullanımları,
ARGEFAR&Helvacızade Sağlık Yayınları, (pp.167-172). İzmir.
9. Baruah A, Bordoloi M, Deka Baruah HP. (2016). Aloe vera: A multipurpose industrial crop.
Industrial Crops and Products, 94, 951–963. [Crossref]
10. IARC Monographs (Online) (2015). International Agency for Research on Cancer (IARC), Vol.
108, (pp. 37–71). Lyon. [www.monographs.iarc]
11. World Health Organization (WHO) (1999). WHO Monographs on Selected Medicinal Plants
(Vol. 1). In: WHO Monographs on Selected Medical Plants. World Health Organization: Geneva,
Switzerland, (pp. 33–49).
12. Femenia, A., Sanchez, E.S., Simal, S., Rossello, C. (1999). Compositional features of
polysaccharides from Aloe vera (Aloe barbadensis Miller) plant tissues. Carbohydrate Polymers,
39, 109–117. [Crossref]
13. Boudreau, M.D., Beland, F.A. (2006). An evaluation of the biological and toxicological properties
of Aloe Barbadensis (Miller), Aloe Vera. Journal of Environmental Science and Health Part C,
24,103–154. [Crossref]
14. Bhuvana, K.B., Hema, N.G., Patil, R.T. (2014). Review on Aloe vera. International Journal of
Advanced Research, 2(3), 677–691.
15. Boudreau, M.D., Mellick, P.W., Olson, G.R., Felton, R.P., Thorn, B.T., Beland, F.A. (2013).
Clear evidence of carcinogenic activity by a whole-leaf extract of Aloe barbadensis Miller (Aloe
vera) in F344/N rats. Toxicological Sciences, 131(1), 26–39. [Crossref]
16. Cosmetic Ingredient Review Expert Panel (2007). Final Report on the Safety Assessment of Aloe
andongensis Extract, Aloe andongensis Leaf Juice, Aloe arborescens Leaf Extract, Aloe
arborescens Leaf Juice, Aloe arborescens Leaf Protoplasts, Aloe barbadensis Flower Extract,
Aloe barbadensis Leaf, Aloe bar. International Journal of Toxicology, 26(2),1-50. [Crossref]
17. Waller, G.R., Mangiafico, S., Ritchey, C.R. (1978). A chemical ınvestigation of Aloe barbadensis
Miller. Proceedings of the Oklahoma Academy of Science, 58, 69–76.
18. Raksha, B., Pooja, S., Babu, S. (2014). Bioactive compounds and medicinal properties of Aloe
vera L.: An update. Journal of Plant Sciences, 2(3), 102–107. [Crossref]
19. López, A., De Tangil, M.S., Vega-Orellana, O., Ramírez, A.S., Rico, M. (2013). Phenolic
constituents, antioxidant and preliminary antimycoplasmic activities of leaf skin and flowers of
Aloe vera (L.) Burm. f. (syn. A. barbadensis Mill.) from the Canary Islands (Spain). Molecules,
18, 4942–4954. [Crossref]
20. Wink, M. (2003). Evolution of secondary metabolites from an ecological and molecular
phylogenetic perspective. Phytochemistry, 64, 3–19. [Crossref]
21. Hamman, J.H. (2008). Composition and applications of Aloe vera leaf gel. Molecules, 13(8),
1599–1616. [Crossref]
22. Ahlawat, K.S., Khatkar, B.S. (2011). Processing, food applications and safety of Aloe vera
products: A review. Journal of food science and technology, 48(5), 525–533. [Crossref]
23. Rodríguez, E.R., Martín, J.D., Romero, C.D. (2010). Aloe vera as a Functional Ingredient in
Foods. Critical Reviews in Food Science and Nutrition, 50, 305–326. [Crossref]
24. Brusick, D., Mengs, U. (1997). Assessment of the genotoxic risk from laxative senna products.
Environmental and Molecular Mutagenesis, 29(1), 1–9. [Crossref]
25. Mascolo, N., Izzo, A.A., Borrelli, F., Capasso, R., Di Carlo, G., Sautebin, L., Capasso, F. (2004).
Healing Powers of Aloes. In: Reynolds T. (Ed), Aloes: The Genus Aloe (e-Book), (pp. 222–251 Boca Raton: CRC Press.
26. European Scientific Cooperative on Phytotherapy (ESCOP). (2014). Aloe barbadensis (Barbados
Aloes). In: Mills S, Hutchins R, (Eds), ESCOP Monographs. Exeter, UK: ESCOP.
27. Motykie, G.D., Obeng, M.K., Heggers, J.P. (2004). Aloe vera in wound healing. In: Reynolds T.
(Ed), Aloes: The Genus Aloe (e-Book), (pp. 252–263). Boca Raton: CRC Press.
28. Sung, C.K. (2006). The History of Aloe. In: Park Y.I., Lee S.K. (Eds). New Perspectives on Aloe
(e-Book), (pp. 7–9). New York: Springer.
29. Georgescu, M., Marinas, O., Popa, M., Stan, T., Lazar, V., Bertesteanu, S.V., Chifıriuc, M.
(2016). Natural Compounds for Wound Healing. In: Worldwide Wound Healing - Innovation in
Natural and Conventional Methods. (pp. 61–89).
30. Ross, I.A. (2001). Medicinal Plants of the World: Chemical constituents, traditional and modern
medicinal uses. Vol. 3 (e-Book). Humana Press.
31. Hormozi, M., Assaei, R., Boroujeni, M.B. (2017). The effect of Aloe vera on the expression of
wound healing factors (TGFβ1 and bFGF) in mouse embryonic fibroblast cell: In vitro study.
Biomedicine&Pharmacotherapy, 88, 610–616. [Crossref]
32. Subramanian, S., Sathish Kumar, D., Arulselvan P. (2006). Wound healing potential of Aloe vera
leaf gel studied in experimental rabbits. Asian Journal of Biochemistry, 1(2),178–185. [Crossref]
33. Sánchez-Machado, D.I., López-Cervantes, J., Sendón, R., Sanches-Silva, A. (2017). Aloe vera:
Ancient knowledge with new frontiers. Trends in Food Science&Technology, 61, 94–102.
[Crossref]
34. Fox, L.T., Mazumder, A., Dwivedi, A., Gerber, M., du Plessis, J., Hamman, J.H. (2017). In vitro
wound healing and cytotoxic activity of the gel and whole-leaf materials from selected Aloe
species. Journal of Ethnopharmacology, 200, 1–7. [Crossref]
35. Visuthikosol, V., Chowchuen, B., Sukwanarat, Y., Sriurairatana, S., Boonpucknavig, V. (1995).
Effect of Aloe vera gel to healing of burn wound a clinical and histologic study. Journal of the
Medical Association of Thailand, 78(8), 403-409.
36. Bahramsoltani, R., Farzaei, M.H., Rahimi, R. (2014). Medicinal plants and their natural
components as future drugs for the treatment of burn wounds: An integrative review. Archives of
Dermatological Research, 306(7), 601–617. [Crossref]
37. Hashemi, S.A., Madani, S.A., Abediankenari, S. (2015). The review on properties of Aloe vera
in healing of cutaneous wounds. BioMed Research International, 2015, 714216. [Crossref]
38. Kumar, S., Yadav, J.P. (2014). Ethnobotanical and pharmacological properties of Aloe vera: a
review. Journal of Medicinal Plants Research, 8(48), 1387–1398.
39. Pugh, N., Ross, S.A., ElSohly, M.A., Pasco, D.S. (2001). Characterization of aloeride, a new
high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity.
Journal of Agricultural and Food Chemistry, 49(2), 1030–1034. [Crossref]
40. Ozsoy, N., Candoken, E., Akev, N. (2009). Implications for degenerative disorders: antioxidative
activity, total phenols, flavonoids, ascorbic acid, β-carotene and α-tocopherol in Aloe vera.).
Oxidative Medicine and Cellular Longevity, 2(2), 99–106.
41. Kaithwas, G., Singh, P., Bhatia, D. (2014). Evaluation of in vitro and in vivo antioxidant potential
of polysaccharides from Aloe vera (Aloe barbadensis Miller) gel. Drug and Chemical Toxicology,
37(2), 135–143. [Crossref]
42. Rodrigues Oliveira, L.L., de Oliveira, A.C.L., Tabrez, S., Shakil, S., Khan, M.I., Asghar, M.N.,
Matias, B.D., Alves da Silva Batista, J.M., Rosal, M.M., Fulgencio de Lima, M.M.D., Ferreira
Gomes, S.R., de Carvalho, R.M., de Moraes, G.P., Oliveira Barros de Alencar, M.V., Islam, M.T.,
de Carvalho Melo-Cavalcante, A.A. (2018). Mutagenic, antioxidant and wound healing properties
of Aloe vera. Journal of Ethnopharmacology, 227, 191–197. [Crossref]
43. Capasso, F., Borrelli, F., Capasso, R., Di Carlo, G., Izzo, A.A., Pinto, L, Mascolo, N., Castaldo,
S., Longo, R. (1998). Aloe and its therapeutic use. Phytotherapy Research, 12, 124–127.
[Crossref]
44. Tizard, I.R., Ramamoorthy, L. (2004). Aloes and the immun system. In: Reynolds T. (Ed), Aloes:
The Genus Aloe (e-Book), (pp. 324–45). Boca Raton: CRC Press
45. Lee, W., Yang, S., Lee, C., Park, E.K., Kim, K.M., Ku, S.K., Bae, J.S. (2019). Aloin reduces
inflammatory gene iNOS via inhibition activity and p-STAT-1 and NF-κB. Food and Chemical
Toxicology, 126, 67–71. [Crossref]
46. Heng, H.C., Zulfakar, M.H., Ng P.Y. (2018), Pharmaceutical Applications of Aloe vera.
Indonesian Journal of Pharmacy, 29(3), 101–116. [Crossref]
47. Maan, A.A., Nazir, A., Khan, M.K.I., Ahmad, T., Zia, R., Murid, M, Abrar, M. (2018). The
therapeutic properties and applications of Aloe vera: A review. Journal of Herbal Medicine, 12,
1-10. [Crossref]
48. Salehi, B., Albayrak, S., Antolak, H., Kręgiel, D., Pawlikowska, E., Sharifi-Rad, M., Uprety, Y.,
T souh Fokou, P.V., Yousef, Z., Zakaria, Z.A., Varoni E.M., Sharopov, F., Martins, N., Iriti M.,
Sharifi-Rad, J. (2018). Aloe genus plants: From farm to food applications and
phytopharmacotherapy. International Journal of Molecular Sciences, 19(9), 2843. [Crossref]
49. Surjushe, A., Vasani, R., Saple, D. (2008). Aloe vera: A short review. Indian Journal of
Dermatology, 53(4), 163–166.
50. Steenkamp, V., Stewart, M.J. (2007). Medicinal applications and toxicological activities of Aloe
products. Pharmaceutical Biology. 45(5), 411–420. [Crossref]
51. Akev, N. (2007). Effect of Aloe vera pulp extract on Ehrlich ascites tumours in mice. European
Journal of Cancer Prevention, 16(2), 151-157. [Crossref]
52. El-Shemy, H., Aboul-Soud, M., Aboul-Enein, K., Nassr-Allah, A., Kabash, A., Yagi, A. (2010).
Antitumor properties and modulation of antioxidant enzymes activity by Aloe vera leaf active
principles isolated via supercritical carbon dioxide extraction. Current Medicinal Chemistry,
17(2), 129–138. [Crossref]
53. Tomasin, R., Gomes-Marcondes, M.C.C. (2011). Oral administration of Aloe vera and honey
reduces walker tumour growth by decreasing cell proliferation and increasing apoptosis in tumour
tissue. Phytotherapy Research, 25, 619–623. [Crossref]
54. Liu, R.H. (2004). Potential synergy of phytochemicals in cancer prevention: mechanism of action.
The Journal of Nutrition, 134(12), 3479–3485. [Crossref]
55. Akaberi, M., Sobhani, Z., Javadi, B., Sahebkar, A., Emami, S.A. (2016). Therapeutic effects of
Aloe spp. in traditional and modern medicine: A review. Biomedicine&Pharmacotherapy, 84,
759–772. [Crossref]
56. Halder, S., Mehta, A.K., Mediratta, P.K. (2013). Aloe vera improves memory and reduces
depression in mice. Nutritional Neuroscience, 16(6), 250–254. [Crossref]
57. Abdollahnejad, F., Mosaddegh, M., Nasoohi, S., Mirnajafi-Zadehc, J., Kamalinejadd, M., Faizi,
M. (2016). Study of sedative-hypnotic effects of Aloe vera L. aqueous extract through behavioral
evaluations and EEG recording in rats. Iranian Journal of Pharmaceutical Research, 15(1), 293–
300.
58. Shida, T., Yagi, A., Nishimura H., Nishioka, I. (1985). Effect of Aloe extract on peripheral
phagocytosis in adult bronchial asthma. Planta Medica, 51(3), 273–275. [Crossref]
59. Kar, A., Panda, S., Bharti, S. (2002). Relative efficacy of three medicinal plant extracts in the
alteration of thyroid hormone concentrations in male mice. Journal of Ethnopharmacology, 81(2),
281–285. [Crossref]
60. EMA Committee on Herbal Medicinal Products (HMPC). (2017). European Union herbal
monograph on Aloe barbadensis Mill . and on Aloe ( various species , mainly Aloe ferox Mill .
and its hybrids), folii succus siccatus. European Medicines Agency: London.
61. Gıda ve Kontrol Genel Müdürlüğü web sitesi. (2018). Aloe vera (L.) Burm. f.’nin Yapraklarından
Elde Edilen Aloe vera Jel ve Renksizleştirilmiş Yaprak Usaresi’nin Gıdalarda Kullanımının
Güvenilirliğinin Değerlendirilmesi Hakkında Bilimsel Görüş. From [www.tarimorman.gov.tr]
Erişim tarihi: 18.02.2019.
62. U.S. FDA. (2002). U.S. Food and Drug Administration - Status of Certain Additional Over-the[1]Counter Drug Category II and III Active Ingredients. Vol. 67. No. 90 / Thursday, May 9, 2002 /
Rules and Regulations. 21 CFR Part 310.
63. Shahzad, M.N., Ahmed, N. (2013). Effectiveness of Aloe vera gel compared with 1% silver
sulphadiazine cream as burn wound dressing in second degree burns. The Journal of the Pakistan
Medical Association, 63(2), 225–230.
64. Irani, P.S., Varaie, S. (2016). Comparison of the effect of Aloe vera gel and nitrofurazone 2% on
epithelialization and granulation tissue formation regarding superficial second-degree burns.
Iranian Journal of Medical Sciences, 41(3), S3.
65. Najafian, Y., Khorasani, Z.M., Najafi, M.N., Hamedi, S., Mahjour, M., Feyzabadi, Z. (2019).
Efficacy of Aloe vera/Plantago major gel in diabetic foot ulcer: A randomized double-blind
clinical trial. Current Drug Discovery Technologies, 16(2), 223-231. [Crossref]
66. Avijgan, M., Alinaghian, M., Esfahani, M.H. (2017). Aloe vera gel as a traditional and
complementary method for chronic skin burn: A case report. Advances in Infectious Diseases.
7(1), 19–25. [Crossref]
67. Avijgan, M., Kamran, A., Abedini, A. (2016). Effectiveness of Aloe vera Gel in Chronic Ulcers
in Comparison with Conventional Treatments (Poster). Iranian Journal of Medical Sciences. 41(3), S30.
68. Panahi, Y. (2015). Comparative trial of Aloe vera/olive oil combination cream versus phenytoin
cream in the treatment of chronic wounds. Journal of Wound Care, 24(10), 62–65. [Crossref]
69. Molazem, Z., Mohseni, F., Younesi, M., Keshavarzi, S. (2014). Aloe vera gel and cesarean wound
healing: A randomized controlled clinical trial. Global Journal of Health Science, 7(1), 203–209.
[Crossref]
70. Syed, T.A. (1996). Management of psoriasis with Aloe vera extract in a hydrophilic cream: A
placebo-controlled, double-blind study. Tropical Medicine and International Health, 1(4), 505–
509. [Crossref]
71. Seyger, M.M.B., Van De Kerkhof, P.C.M., Van Vlijmen-Willems, I.M.J.J., De Bakker, E.S.M.,
Zwiers, F., De Jong, E.M.G.J. (1998). The efficacy of a new topical treatment for psoriasis: Mirak.
The Journal of the European Academy of Dermatology and Venereology, 11, 13–18. [Crossref]
72. Haddad, P., Amouzgar-Hashemi, F., Samsami, S., Chinichian, S., Oghabian, M.A. (2013). Aloe
vera for prevention of radiation-induced dermatitis: A self-controlled clinical trial. Current
Oncology, 20, 345–348. [Crossref]
73. Yogi, V., Singh, O.P., Mandloi, V., Ahirwar, M. (2018). Role of topical Aloe vera gel in the
recovery of high-grade, radiation-induced dermatitis. Clinical Cancer Investigation Journal, 7,
167–170. [Crossref]
74. Paulsen, E., Korsholm, L., Brandrup, F. (2005). A double-blind, placebo-controlled study of a
commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. The Journal of
the European Academy of Dermatology and Venereology, 19, 326–331. [Crossref]
75. Choonhakarn, C., Busaracome, P., Sripanidkulchai, B., Sarakarn, P. (2010). A prospective,
randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild
to moderate plaque psoriasis. The Journal of the European Academy of Dermatology and
Venereology, 24, 168–172. [Crossref]
76. Ahmadloo, N., Kadkhodaei, B., Omidvari, S., Mosalaei, A., Ansari, M., Nasrolahi, H., Hamedi
S.H., Mohammadianpanah, M. (2017). Lack of Prophylactic Effects of Aloe vera Gel on
Radiation Induced Dermatitis in Breast Cancer Patients. Asian Pacific Journal of Cancer
Prevention, 18(4), 1139–1143.[Crossref]
77. Merchant, T.E., Bosley, C., Smith,J., Baratti, P., Pritchard, D., Davis, T., Li, C., Xiong, X. (2007).
A phase III trial comparing an anionic phospholipid-based cream and Aloe vera-based gel in the
prevention of radiation dermatitis in pediatric patients. Radiation Oncology, 2, 45. [Crossref]
78. Olsen, D.L., Raub, W., Bradley, C., Johnson, M., Macias, J.L., Love, V., Markoe, A. (2001). The
effect of Aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients
undergoing radiation therapy. Oncology Nursing Forum, 28(3), 543-547.
79. Hoopfer, D., Holloway, C., Gabos, Z., Alidrisi, M., Chafe, S., Krause, B., Lees, A., Mehta, N.,
Tankel, K., Strickland, F., Hanson, J., King, C., Ghosh, S., Severin, D. (2015). Three-arm
randomized phase III trial: Quality Aloe and placebo cream versus powder as skin treatment
during breast cancer radiation therapy. Clinical Breast Cancer, 15(3), 181-190.e4. [Crossref] in cancer radiation: An updated comprehensive review. Complementary Therapies in Clinical
Practice, 35, 126–130. [Crossref]
80. Farrugia, C.J.E., Burke, E.S., Haley, M.E., Bedi, K.T., Gandhi, M.A. (2019). The use of Aloe vera
81. Yee, C., Wang, K., Asthana, R., Drost, L., Lam, H., Lee, J., Vesprini, D., Leung, E., Deangelis,
C., Chow, E. (2018). Radiation-induced skin toxicity in breast cancer patients: A systematic
review of randomized trials. Clinical Breast Cancer, 18(5), 825–840. [Crossref]
82. Chew, Y.L., Al-Nema, M., Ong, V.W.M. (2018). Management and treatment of atopic dermatitis
with modern therapies, complementary and alternative medicines: a review. Oriental Pharmacy
and Experimental Medicine, 18, 67–76. [Crossref]
83. Hajheydari, Z., Saeedi, M., Morteza-Semnani, K., Soltani, A. (2014). Effect of Aloe vera topical
gel combined with tretinoin in treatment of mild and moderate acne vulgaris: A randomized,
double-blind, prospective trial. Journal of Dermatological Treatment, 25(2), 123–129. [Crossref]
84. Mazzarello, V., Donadu, M., Ferrari, M., Piga, G., Usai, D., Zanetti, S., Sotgiu, M.A. (2018).
Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to
erythromycin cream: two double-blind investigations. Clinical Pharmacology: Advances and
Applications, 10, 175–181. [Crossref]
85. Syed, T.A. (1996). Aloe vera extract 0.5% in hydrophilic cream versus Aloe vera gel for the
management of genital herpes in males. A placebo-controlled, douhle- blind, comparative study.
The Journal of the European Academy of Dermatology and Venereology, 7, 294–5. [Crossref]
86. Syed, T.A., Afza, M., Ahmad, S.A., Holt, A., Ahmad, S.A., Ahmad, S. (1997). Management of
genital herpes in men with 0.5% Aloe vera extract in a hydrophilic cream: A placebo-controlled
double-blind study. Journal of Dermatological Treatment, 8, 99–102. [Crossref]
87. Vardy, D., Cohen, A., Tchetov, T., Medvedovsky, E., Biton, A. (1999). A double-blind, placebo[1]controlled trial of an Aloe vera (A . barbadensis) emulsion in the treatment of seborrheic
dermatitis. Journal of Dermatological Treatment, 10(1), 7–11. [Crossref]
88. Panahi, Y., Sharif, M.R., Sharif, A., Beiraghdar, F., Zahiri, Z., Amirchoopani, G., Marzony, E.T.,
Sahebkar, A. (2012). A randomized comparative trial on the therapeutic efficacy of topical Aloe
vera and Calendula officinalis on diaper dermatitis in children. The Scientific World Journal,
2012, 810234. [Crossref]
89. Badelbuu, S.G., Javadzadeh, Y., Jabraeili, M., Heidari, S., Bostanabad, M.A. (2018). Evaluation
of the effect of Aloe vera ointment with chamomile ointment on severity of children’s diaper
dermatitis: A randomized, double-blind clinical trial. Middle East Journal of Family Medicine,
16(3), 47–51.
90. Zhang, Y., Liu, W., Liu, D., Zhao, T., Tian, H. (2016). Efficacy of Aloe vera supplementation on
prediabetes and early non-treated diabetic patients: A systematic review and meta-analysis of
randomized controlled trials. Nutrients. 8(7), 388. [Crossref]
91. Walid, R., Hafida, M., Abdelhamid, E.H.I., Reda, B., Rachid, A., Mohamed, B. (2018). Beneficial
effects of Aloe vera gel on lipid profile, lipase activities and oxidant/antioxidant status in obese
rats. Journal of Functional Foods, 48, 525–532. [Crossref]
92. Choi, H.C., Kim, S.J., Son, K.Y., Oh, B.J., Cho, B.L. (2013). Metabolic effects of Aloe vera gel
complex in obese prediabetes and early non-treated diabetic patients: Randomized controlled trial.
Nutrition, 29(9), 1110–1114. [Crossref]
93. Yun, J.M., Singh, S., Jialal, R., Rockwood, J., Jialal, I., Devaraj, S. (2010). A randomized
placebo-controlled crossover trial of Aloe vera on bioavailability of Vitamins C and B12, blood
glucose, and lipid profile in healthy human subjects. Journal of Dietary Supplements. 7(2), 145–
153. [Crossref]
94. Mentreddy, S., Mohamed, A., Rimando, A. (2005). Medicinal plants with hypoglycemic/ anti[1]hyperglycemic properties: A review. Association for the Advancement of Industrial Crops
Conference, 20, 341–353.
95. Reynolds, T., Dweck, A.C. (1999). Aloe vera leaf gel: A review update. Journal of
Ethnopharmacology. 68(1–3), 3–37. [Crossref]
96. Park, C.H., Son, H.U., Yoo, C.Y., Lee, S.H. (2017). Low molecular-weight gel fraction of Aloe
vera exhibits gastroprotection by inducing matrix metalloproteinase-9 inhibitory activity in
alcohol-induced acute gastric lesion tissues. Pharmaceutical Biology, 55(1), 2110–2115.
[Crossref]
97. Gopinathan, S., Rameela, N. (2014). Anti-ulcer activity of aloe vera juice and Aloe vera and amla
fruit combined juice in ethanol induced ulcerated rats. International Journal of Pharmacy and
Pharmaceutical Sciences, 6(6), 190–197.
98. Keshavarzi, Z., Rezapour, T.M., Vatanchian, M., Hesari, M.Z., Haghighi, H.N., Izanlu, M.,
Sabaghian, M., Shahveisi, K. (2014). The effects of aqueous extract of Aloe vera leaves on the
gastric acid secretion and brain and intestinal water content following acetic acid- induced gastric
ulcer in male rats. Avicenna Journal of Phytomedicine, 4(2), 137–143.
99. Panahi, Y. (2015). Efficacy and safety of Aloe vera syrup for the treatment of gastroesophageal
reflux disease: A pilot randomized positive-controlled trial. Journal of Traditional Chinese
Medicine. 35(6), 632–636. [Crossref]
100. Hong, S.W., Chun, J., Park, S., Lee, H.J., Im, J.P., Kim, J.S. (2018). Aloe vera ıs effective and
safe in short-term treatment of ırritable bowel syndrome: A systematic review and meta-analysis.
Journal of Neurogastroenterology and Motility, 24(4), 528–535. [Crossref]
101. Langmead, L. (2004). Randomized, double-blind, placebo-controlled trial of oral Aloe vera gel
for active ulcerative colitis. Alimentary Pharmacology&Therapeutics, 19(7), 739–747. [Crossref]
102. Rahmani, N., Khademloo, M., Vosoughi, K., Assadpour, S. (2014). Effects of Aloe vera cream
on chronic anal fissure pain, wound healing and hemorrhaging upon defection: A prospective
double blind clinical trial. European Review for Medical and Pharmacological Sciences, 18,
1078–1084.
103. Alinejad-Mofrad, S., Foadoddini, M., Saadatjoo, S.A., Shayesteh, M. (2015). Improvement of
glucose and lipid profile status with Aloe vera in pre-diabetic subjects: A randomized controlled[1]trial. Journal of Diabetes & Metabolic Disorders, 14, 22. [Crossref]
104. Zarrintan, A., Mobasseri, M., Zarrintan, A., Ostadrahimi, A. (2015). Effects of Aloe vera
supplements on blood glucose level and lipid profile markers in type 2 diabetic patients: A
randomized clinical trial. Pharmaceutical Sciences, 21, 65–71. [Crossref]
105. Huseini, H.F., Kianbakht, S., Hajiaghaee, R., Dabaghian, F.H. (2012) Anti-hyperglycemic and
anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Planta Medica, 78, 311–316.
[Crossref]
106. Yagi, A., Hegazy, S., Kabbash, A., Wahab, E.A.E. (2009). Possible hypoglycemic effect of Aloe
vera L. high molecular weight fractions on type 2 diabetic patients. Saudi Pharmaceutical
Journal, 17(3), 209–215. [Crossref]
107. Al-Maweri, S.A., Ashraf, S., Lingam, A.S., Alqutaibi, A., Abdulrab, S., Alaizari, N., Halboub, E.
(2018). Aloe vera in treatment of oral submucous fibrosis: A systematic review and meta-analysis.
Journal of Oral Pathology and Medicine, 48(2), 99-107. [Crossref]
108. Nair, G.R. (2016). Clinical Effectiveness of Aloe vera in the Management of Oral Mucosal
Diseases-A Systematic Review. Journal of Clinical and Diagnostic Research. 10(8), ZE01–7.
[Crossref]
109. Gao,Y., Kuok, K.I., Jin, Y., Wang, R. (2018). Biomedical applications of Aloe vera. Critical
Reviews in Food Science and Nutrition, 59(1), S244-S256. [Crossref]
110. Koga, A.Y., Pereira, A.V., Lipinski, L.C., Oliveira, M.R.P. (2018). Evaluation of wound healing
effect of alginate films containing Aloe vera (Aloe barbadensis Miller) gel. Journal of
Biomaterials Applications, 32(9), 1212–1221. [Crossref]
111. Pereira, G.G., Guterres, S.S., Balducci, A.G., Colombo, P., Sonvico, F. (2014). Polymeric films
loaded with vitamin e and Aloe vera for topical application in the treatment of burn wounds.
BioMed Research International, 2014, 641590. [Crossref]
112. Krishnaveni, V., Aparna, B. (2014). Microencapsulation of copper enriched Aloe gel curative
garment for atopic dermatitis. Indian Journal of Traditional Knowledge, 13(4), 795–803.
113. Ghayempour, S., Montazer, M., Mahmoudi Rad, M. (2016). Encapsulation of Aloe vera extract
into natural Tragacanth Gum as a novel green wound healing product. International Journal of
Biological Macromolecules, 93, 344–349. [Crossref]
114. Tippayawat, P., Phromviyo, N., Boueroy, P., Chompoosor, A. (2016). Green synthesis of silver
nanoparticles in Aloe vera plant extract prepared by a hydrothermal method and their synergistic
antibacterial activity. PeerJ, 4, e2589. [Crossref]
115. Morgan, M., Bone, K., Mills, S., McMillan, J. (2005). Aloe: Safety monograph. In S. Mills ve K.
Bone (Eds.), The essential guide to herbal safety (pp. 233–240). St. Louis (MO): Elsevier
Churchill Livingstone.
116. Gupta, RC., Chang, D., Nammi, S., Bensoussan, A., Bilinski, K., Roufogalis, BD. (2017).
Interactions between antidiabetic drugs and herbs: An overview of mechanisms of action and
clinical implications. Diabetology and Metabolic Syndrome, 9, 59. [Crossref]
117. Braun, L., Cohen, M. (2007). Herbs ve Natural Supplements, Elsevier, Australia.
118. Parlati, L., Voican, C.S., Perlemuter, K., Perlemuter, G. (2017). Aloe vera-induced acute liver
injury: A case report and literature review. Clinics and Research in Hepatology and
Gastroenterology, 41(4), e39–e42. [Crossref]
119. Tekin, F., Şahin, O. Z., Karasu, Z., Nart, D., Özütemiz, Ö., Ersöz, G., Batur, Y., İlter, T. (2006).
Aloe vera’ya bağlı ciddi toksik hepatit:Olgu sunumu. Akademik Gastroenteroloji Dergisi, 5(2), 134–136.
120. Kanat, O., Ozet, A., Ataergin, S. (2006). Aloe vera-induced acute toxic hepatitis in a healthy
young man. European Journal of Internal Medicine, 17, 589.[Crossref]
121. Baretta, Z., Ghiotto, C., Marino, D., Jirillo, A. (2009). Aloe-induced hypokalemia in a patient with
breast cancer during chemotherapy. Annals of Oncology, 20, 1445–1446. [Crossref]
122. Maenthaisong, R., Chaiyakunapruk, N., Niruntraporn, S., Kongkaew, C. (2007). The efficacy of
Aloe vera used for burn wound healing: A systematic review. Burns, 33, 713–718. [Crossref]
123. National Toxicology Program. (2016). Aloe vera Fact Sheet. From [www.niehs.nih.gov] Erişim
tarihi: 08.04.2018.
124. International Aloe Science Council (IASC). (2013). Aloe vera Quality Standard. From
[www.iasc.org] Erişim tarihi: 03.04.2018.
125. International Aloe Science Council (IASC). (2009). IASC Labeling Guidance. From
[www.iasc.org] Erişim tarihi: 03.04.2018.
126. NCCIH. (2016). Aloe Vera. From [nccih.nih.gov] Erişim tarihi: 16.04.2019.
127. European Food Safety Authority (EFSA). (2012). Compendium of botanicals reported to contain
naturally occuring substances of possible concern for human health when used in food and food
supplements. EFSA Journal, 10(5):2663.
128. EMA Committee on Herbal Medicinal Products (HMPC). (2016). Assessment report on Aloe
barbadensis Mill. and on Aloe (various species, mainly Aloe ferox Mill. and its hybrids), folii
succus siccatus. From [www.ema.europa.eu] Erişim tarihi: 06.12.2018.
129. The European Community. (2008). European Community Position Codex Committee On Food
Additives. From [ec.europa.eu] Erişim tarihi: 11.11.2018.
130. Radha, M.H., Laxmipriya, N.P. (2015). Evaluation of biological properties and clinical
effectiveness of Aloe vera: A systematic review. Journal of Traditional and Complementary
Medicine, 5(1), 21–26. [Crossref]
131. Fox, L.T., Mazumder, A., Dwivedi, A., Gerber, M., du Plessis, J., Hamman, J.H. (2017). In vitro
wound healing and cytotoxic activity of the gel and whole-leaf materials from selected Aloe
species. Journal of Ethnopharmacology, 200, 1–7. [Crossref]
132. Habtemariam, S. (2017). Could We Really Use Aloe vera Food Supplements to Treat Diabetes?
Quality Control Issues. Evidence-Based Complementary and Alternative Medicine, 2017,
4856412. [Crossref]
133. Ankara Ecz. Fak. Derg., 45(3): 674-698, 2021